Ionizing radiation induces changes in profile of metabolites in serum of cancer patients

  • Małgorzata Roś-Mazurczyk Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice
  • Anna Wojakowska Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice
  • Łukasz Marczak Polish Academy of Science, Institute of Bioorganic Chemistry, Poznań
  • Krzysztof Polański University of Warvick, Coventry
  • Monika Pietrowska Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice
  • Karol Jelonek Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice
  • Iwona Domińczyk Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice
  • Agata Hajduk Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice
  • Tomasz Rutkowski Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice
  • Krzysztof Składowski Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice
  • Piotr Widłak Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice
DOI: https://doi.org/10.18388/abp.2016_1301
Keywords: head and neck cancer, mass spectrometry, metabolomics, radiation response, serum metabolome,

Abstract

Radiotherapy causes molecular changes observed at the level of body fluids, which are potential biomarker candidates for assessment of radiation exposure. Here we analyzed radiotherapy-induced changes in profile of small metabolites detected in sera of head and neck cancer patients using the GC/MS approach. There were about 30 compounds, including carboxylic acids, sugars, amines and amino acids, which levels significantly differed between pre-treatment and post-treatment samples. Among metabolites upregulated by radiotherapy was 3-hydroxy-butyric acid, which level increased about 10-fold in post-treatment samples. Compounds affected by irradiation were associated with several metabolic pathways, including catecholamine biosynthesis and amino acid metabolism.

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Published
2016-11-04
Issue
Vol. 64 No. 1 (2017)
Section
Articles

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