Structure and function of RNA elements present in enteroviral genomes

Mariola Dutkiewicz; Aleksandra Stachowiak; Agata Swiatkowska; Jerzy Ciesiołka

doi:10.18388/abp.2016_1337

Mariola Dutkiewicz Institute of Bioorganic Chemistry Polish Academy of Sciences ul. Z. Noskowskiego 12/14 61-704 Poznan
Aleksandra Stachowiak Institute of Bioorganic Chemistry Polish Academy of Sciences ul. Z. Noskowskiego 12/14 61-704 Poznan
Agata Swiatkowska Institute of Bioorganic Chemistry Polish Academy of Sciences ul. Z. Noskowskiego 12/14 61-704 Poznan
Jerzy Ciesiołka Institute of Bioorganic Chemistry Polish Academy of Sciences ul. Z. Noskowskiego 12/14 61-704 Poznan

DOI: https://doi.org/10.18388/abp.2016_1337

Keywords: Enterovirus, poliovirus, coxsackievirus B3, RNA structure, structural RNA element, cis-acting element

Abstract

Enteroviruses are small RNA(+) viruses that encode one open reading frame flanked by two extensive noncoding regions carrying structural RNA regulatory elements that control replication and translation processes. For a long time the central, coding region was thought to remain single-stranded and its only function was supposed to be as the template for polyprotein synthesis. It turned out, however, that the protein coding region also encodes important RNA structures crucial for the viral life cycle and virus persistence in host cells. This review considers the RNA structures in enteroviral genomes identified and characterized to date.

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