MicroRNA biogenesis: Epigenetic modifications as another layer of complexity to the microRNA expression regulation

Susheel Sagar Bhat; Artur Jarmolowski; Zofia Szweykowska-Kulinska

doi:10.18388/abp.2016_1370

Susheel Sagar Bhat Adam Mickiewicz University
Artur Jarmolowski Adam Mickiewicz University
Zofia Szweykowska-Kulinska Adam Mickiewicz University

DOI: https://doi.org/10.18388/abp.2016_1370

Keywords: microRNA, microRNA biogenesis, m6A modification, m6A RNA methyltransferase

Abstract

Since their discovery, microRNAs have led to a huge shift in our understanding of the regulation of key biological processes. The discovery of epigenetic modifications that affect microRNA expression has added another layer of complexity to the already tightly controlled regulatory machinery. The presence of N6-methyl-adenosine (m⁶A) mark and its critical importance in miRNA biogenesis in animals adds to our understanding of the regulatory mechanisms.

Author Biographies

Susheel Sagar Bhat, Adam Mickiewicz University

Department of Gene Expression, Institute of Molecular Biology and Biotechnology

PhD Student

Artur Jarmolowski, Adam Mickiewicz University

Department of Gene Expression, Institute of Molecular Biology and Biotechnology

Professor

Zofia Szweykowska-Kulinska, Adam Mickiewicz University

Department of Gene Expression, Institute of Molecular Biology and Biotechnology

Professor

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