Mechanisms of type I interferon action and its role in infections and diseases transmission in mammals

Weronika Ratajczak; Paulina Niedźwiedzka-Rystwej; Beata Tokarz-Deptuła; Wiesław Deptuła

doi:10.18388/abp.2016_1403

Weronika Ratajczak student of Scientific Circle of Microbiologists, Faculty of Biology, University of Szczecin
Paulina Niedźwiedzka-Rystwej Department of Immunology, Faculty of Biology, University of Szczecin, Poland
Beata Tokarz-Deptuła Department of Immunology, Faculty of Biology, University of Szczecin, Poland
Wiesław Deptuła Department of Microbiology, Faculty of Biology, University of Szczecin, Poland

DOI: https://doi.org/10.18388/abp.2016_1403

Keywords: interferon, signaling pathway, infection, mammal

Abstract

Interferons (IFN) are pivotal regulators of immunological processes. The paper describes mainly type I interferons -α and –β and its recently recounted signaling pathways, especially ISG – interferon stimulated genes, having a crucial role in regulating IFN recruitment. Moreover, the paper shows the data on the role of interferons -α and –β in infections – not only commonly known viral infections, but also bacterial, fungal and parasitic.

References

Alsharifi M, Mullbacher A, Regner M (2008) Inteferon type I responses in primary and secondary infections. Immunol Cell Biol 86: 239-245.

Bonjardim CA (2005) Interferons (IFNs) are key cytokines in both innate and adaptative antiviral immune responses and viruses counteract IFN action. Microbes Infect 7: 569-578.

Casanova JL, Holland SM, Notarangelo LD (2012) Inborn errors of human JAKs and STATs. Immunity 36: 515-528.

Chijioke O, Munz C (2013) Dendritic cell derived cytokines in human natural killer cell differentiation and activation. Front Immunol 4: 1-7, doi: 10.3389/fimmu.2013.00365. eCollection 2013.

Crouse J, Kalinke U, Oxenius A (2015) Regulation of antiviral T cell responses by type I interferons. Nat Rev Immuonol 15: 231-243.

Davidson S, Maini MK, Wack A (2015) Disease – promoting effects of type I interferons in viral, bacterial and coinfections. J Interferon Cytokine Res 35: 252-264.

Durbin JE, Fernandes-Sesma A, Lee CK, Rao D, Frey AB, Moran TM, Vukmanovic S, Garcia-Sastre A, Levy DE (2000) Type I IFN modulates innate and specific antiviral immunity. J Immunol 164: 4220-4228.

Durbin RK, Kotenko SV, Durbin JE (2013) Interferon induction and function at the mucosal surface. Immunol Rev 255: 25-39.

Gessani S, Conti L, Del Corno M, Belardelli F (2014) Type I interferons as regulators of human antigen presenting cell functions. Toxins 6: 1696-1723.

Gonzales-Navajas JM, Lee J, David M, Raz E (2012) Immunomodulatory functions of type I interferons. Nat Rev Immunol 12: 125-135.

Goubau D, Deddouche S, Reis e Sousa C (2013) Cytosolic sensing of viruses. Immunity 28: 855-869.

Guarda G, Braun M, Staehli F, Tardivel A, Mattmann C, Foster I, Farlik M, Decker T, Du Pasqquier RA, Romero P, Tschopp J (2011) Type I interferon inhibits interleukin – 1 production and inflammasome activation. Immunity 34: 213-223.

Hastings AK, Erickson JJ, Schuster JE, Boyd K.L, Tollefson SJ, Johanson M, Gilchuk P, Joyce S, Williams JV (2015) Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication. J Virol 98: 4405-420.

Ho HH, Ivashkin LB (2006) Role of STAT3 in type I interferon responses. Negative regulation of STAT1 – dependent inflammatory gene activation. J Biol Chem 281: 14111-14118.

Ishikawa H, Ma Z, Barber GN (2009) STING regulates intracellular DNA – mediated, type I interferon – dependent innate immunity. Nature 461: 788-792.

Ivashkiv LB, Donlin LT (2014) Regulation of type I interferon responses. Nat Rev Immunol 14: 36-49.

Kiefer K, Oropallo MA, Cancro MP, Marshak-Rothstein A (2012) Role of type I interferons in the activation of autoreactive B cells. Immunol Cell Biol 90: 498-504.

Killip MJ, Fodor E, Randall RE (2015) Influenza virus activation of the interferon system. Virus Res 209: 11-22, doi: 10.1016/j.virusres.2015.02.003.

Koyama S, Ishii KJ, Coban C, Akira S (2008) Innate immune response to viral infection. Cytokine 43: 336-341.

Kudchodkar SB, Levine B (2009) Viruses and autophagy. Rev Med Virol 19: 359-378.

Lee HK, Lund JM, Ramanthan B, Mizushima N, Iwasaki A (2007) Autophagy – dependent viral recognition by plasmocytoid dendritic cells. Science 315: 1398-1401.

Lee HK, Iwasaki A (2008) Autophagy and antiviral immunity. Curr Opin Immunol 20: 23-29.

Levin D, Schneider WM, Hoffmann HH, Yarden G, Busetto AG, Manor O, Sharma N, Rice CM, Schreiber G (2014) Multifaced activities of type I interferon are revealed by s receptor antagonist. Sci Signal doi: 10.1126/scisignal.2004998.

Levine B, Mizushima N, Virgin HW (2011) Autophagy in immunity and inflammation. Nature 469: 323-335.

Liu X, Wang Q, Pan Y, Wang C (2015) Sensing and responding to cytosolic viruses invasion: an orchestra of kaleidoscopic ubiquitinations. Cytokine Growth Factor Rev 26: 379-387.

Lopez C.B, Yount JS, Hermesh T, Moran TM (2006) Sendai virus infection efficient adaptive immunity independence of type I interferons. J Virol 80: 4538-4545.

Lousberg EL, Fraser CK, Tovey MG, Diener KR, Hayball JD (2010) Type I interferons mediate the innate cytokine response to recombinant fowlpox virus but not induction of plasmocytoid dendritic cell – dependent adaptive immunity. J Vorol 84: 6549-6563.

Malireddi RKS, Kanneganti TD (2013) Role of type I inflammasome activation, cell death, and disease during microbial infection. Front Cell Infect Microbiol 3: 1-11.

Malmagaard L (2004) Induction and regulation of IFN during viral infections. J Interferon Cytokine Res 24: 439-454.

McNab F, Mayer-Barber K, Sher A, Wack A, O’GArra A (2015) Type I interferons in infectious disease. Nat Rev Immunol 15: 87-103.

Moulin HR, Liniger M, Python S, Guzylack-Piriou L, Ocana-Macchi M, Ruggi N, Summerfield A (2011) High interferon type I responses in the lung, plasma and spleen during highly pathogenic H5N1 infection of chicken. Vet Res 42: 1-6.

Onoguchi K, Yoneyama M, Takemura A, Akira S, Taniguchi T, Namiki H, Fujita T (2007) Viral infections activate Tees I and III interferon genes through a common mechanizm. J Biol Chem 282: 7576-7581.

Ou R, Zhou S, Huang L, Moskophidis D (2001) Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cell. J Virol 75: 8407-8423.

Paludan SR, Bowie AG (2013) Immune sensing of DNA. Immunity 38: 870-880.

Pothlichet J, Meunier I, Davis BK, Ting JPY, Skamene E, Von Messling V, Vidal SM (2013) Type I IFN triggers RIG-I/TLR3/NLRP3 – dependent inflammasome activation in influenza A virus infected cells. PLoS Pathog 9: 1-14. doi: 10.1371/journal.ppat.1003256

Ramos HJ, Gale M Jr (2011) RIG – I like receptors and their signaling cross talk in the regulation of antiviral immunity. Curr Opin Virol 1: 167-176.

Rathinam VA, Fitzgerald KA (2011) Innate immune sensing of DNA viruses. Virology 411: 153-162.

Rauch I, Muller M, Decker T (2013) The regulation of inflammation by interferons and their STATs. JAKSTAT 2: 1-13, doi: 10.4161/jkst.23820.

Richards KH, Macdonald A (2011) Putting the brakes on the anti-viral response: negative regulators of type I interferons (IFN) production. Microbes Infect 13: 291-302.

Sadler AJ, Williams BRG (2008) Interferon – inducible antiviral effectors. Nat Rev Immunol 8: 559-568.

Sandler NG, Bosinger SE, Estes JD, Zhu RTR, Tharp G.K, Boritz E, Levin D, Wijeyesinghe S, Makamdop KN, del Prete GQ, Hill BJ, Timmer JK, Reiss E, Yarden G., Darko S, Contijoch E, Todd JP, Silvestri G, Nason M, Norgren RB Jr, Keele BF, Rao S, Langer JA, Lifson JD, Schreiber G, Douek DC (2014) Type I interferon response in rhesus macaques prevent SIV infection and slow disease progression. Nature 511: 601-605.

Schmeisser H, Bekisz J, Zoon KC, (2014) New function of type I IFN: induction of autophagy. J Interferon Cytokine Res 34: 71-78.

Stackaruk ML, Lee AJ, Ashkar AA (2013) Type I interferon regulation of natural killer cell function in primary and secondary infections. Expert Rev Vaccines 12: 875-884.

Swiecki M, Colonna M (2010) Unraveling the functions of plasmocytoid dendritic cells during viral infections, autoimmunity and tolerance. Immunol Rev 234: 142-162.

Swiecki M, Colonna M (2011) Type I interferons: diversity of sources, production pathways and effects on immune responses. Curr Opin Virol 1: 463-475.

Tang F, Du Q, Liu YJ (2010) Plasmocytoid dendritic cells in antiviral immunity and autoimmunity. Sci China Life Sci 53; 172-182.

Taylor KE, Mossman KL (2013) Recent advances in understanding viral evasion of type I interferon. Immunology 138: 190-197.

Trinchieri G (2010) Type I interferon: friend or foe? J Exp Med 207: 2053-2063.

Urban SL, Welsh RM (2014) Out-of-sequence signal 3 as a mechanism for virus-induced immune suppression of CD8 T cell responses. PLoS Pathog 10: 1-17, doi: 10.1371/journal.ppat.1004357.

Vermeire J, Iannucci V, Naessens E, Van Landeghem K, Vanderstraeten., Van Damme J, Verhasselt B (2015) HIV-1 infection induces a type I IFN responses in primary CD4+ T cells. Retrovirology doi: 10;1186/1742-4690-10-S1-P95.

White MJ, Kile B (2015) Stressed mitochondria sound the alarm. Immunol Cell Biol 93: 427-428.

Yan N, Chen ZJ (2012) Intrinsic antiviral immunity. Nat Immunol 13: 214-222.

Yesebrant de Lendock L, Martinet V (2014) Interferon regulatory factor 3 in adaptive immune responses. Cell Mol Life Sci 71: 3873-3883.

Zhao W (2013) Negative regulation of TBK1 – mediated antiviral immunity. FEBS Lett; 587: 542-548.