Mitochondrial DNA in pediatric leukemia patients

Agata Kodroń; Magda Ghanim; Katarzyna K. Krawczyk; Anna Stelmaszczyk-Emmel; Katarzyna Tońska; Urszula Demkow; Ewa Bartnik

doi:10.18388/abp.2016_1444

Agata Kodroń Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, 5a Pawińskiego Str., 02-106 Warsaw, Poland
Magda Ghanim Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, 5a Pawińskiego Str., 02-106 Warsaw, Poland
Katarzyna K. Krawczyk Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, 5a Pawińskiego Str., 02-106 Warsaw, Poland
Anna Stelmaszczyk-Emmel Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, 63a Żwirki i Wigury Str., 02-091 Warsaw, Poland
Katarzyna Tońska Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, 5a Pawińskiego Str., 02-106 Warsaw, Poland
Urszula Demkow Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, 63a Żwirki i Wigury Str., 02-091 Warsaw, Poland
Ewa Bartnik Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, 5a Pawińskiego Str., 02-106 Warsaw, Poland Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 5a Pawińskiego Str., 02-106 Warsaw, Poland

DOI: https://doi.org/10.18388/abp.2016_1444

Keywords: pediatric ALL, mtDNA, chemotherapy

Abstract

Numerous studies of mitochondrial DNA (mtDNA) in cancer have shown differences between mtDNA sequences in tumor and normal tissue and at various stages of cancer treatment in the same patient. However, there is little data on acute lymphoblastic leukemia (ALL), the most common type of leukemia in children. In this study we compared mitochondrial sequence variation in the D-loop region and in 5 genes of mtDNA in bone marrow samples of 6 pediatric patients with ALL at various stages of therapy. We found several common polymorphisms and one variant at position 3688 whose level varied during leukemia treatment. Our results suggest that mitochondrial DNA mutations, whose levels change during patient treatment, could be potential biomarkers for monitoring treatment efficacy and disease progression.

Author Biography

Agata Kodroń, Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, 5a Pawińskiego Str., 02-106 Warsaw, Poland

Faculty of Biology, PhD

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