Endothelial progenitor cells participation in cardiovascular and kidney diseases: a systematic review

Jolanta Kiewisz; Monika M. Kaczmarek; Anna Pawlowska; Zbigniew Kmiec; Tomasz Stompor

doi:10.18388/abp.2016_1284

Endothelial progenitor cells participation in cardiovascular and kidney diseases: a systematic review

Jolanta Kiewisz
Monika M. Kaczmarek
Anna Pawlowska
Zbigniew Kmiec
Tomasz Stompor

DOI: https://doi.org/10.18388/abp.2016_1284

Abstract

Endothelial progenitor cells (EPCs) represent a small population of blood cells (5-40 cells/mm³), with an ability to differentiate into endothelial cells that form the lining of the blood vessels and contribute to postnatal angiogenesis. Abundant evidence shows that recruitment of EPCs from the bone marrow, the monocyte/macrophage lineage and the organs facilitate the endothelial regeneration and repair. Changes in the number of EPCs were observed in both, chronic kidney and cardiovascular diseases. Thus, these cells were tested for usage in diagnosis and therapy. In this paper, we review the current knowledge on the EPC biology and contribution of these cells to the kidney and cardiovascular diseases.

Published

2016-06-30

Issue

Vol. 63 No. 3 (2016)

Section

Articles

Acta Biochimica Polonica is an OpenAccess quarterly and publishes four issues a year. All contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.