Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer.

Katarzyna Linkowska; Arkadiusz Jawień; Andrzej Marszałek; Katarzyna Skonieczna; Tomasz Grzybowski

Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer.

Katarzyna Linkowska The Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Institute of Forensic Medicine, Department of Molecular and Forensic Genetics, Bydgoszcz, Poland.;
Arkadiusz Jawień The Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Chair of Vascular Surgery and Angiology, Bydgoszcz, Poland.;
Andrzej Marszałek The Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Chair & Department of Clinical Pathomorphology, Bydgoszcz, Poland.;
Katarzyna Skonieczna The Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Institute of Forensic Medicine, Department of Molecular and Forensic Genetics, Bydgoszcz, Poland.;
Tomasz Grzybowski The Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Institute of Forensic Medicine, Department of Molecular and Forensic Genetics, Bydgoszcz, Poland.;

Abstract

Mitochondrial DNA polymerase gamma (POLG) is the only DNA polymerase involved in maintaining the mitochondrial genome. Recent studies demonstrated an association of CAG repeat polymorphism in the second exon of POLG gene with the risk of cancer. We investigated the CAG repeat variability in the POLG gene in tumor and non-tumor tissues from colorectal cancer patients and in DNA samples isolated from blood obtained from age-matched healthy persons. Somatically occuring CAG-repeat alterations in cancer tissues have been observed in 10% of patients, but no association has been found between the CAG repeat variants in the POLG gene and colorectal cancer risk.

Published

2015-08-28

Issue

Vol. 62 No. 3 (2015)

Section

Articles

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