Mapping of the influenza A hemagglutinin serotypes evolution by the ISSCOR method.

Jan P Radomski; Piotr P Słonimski; Włodzimierz Zagórski-Ostoja; Piotr Borowicz

doi:10.18388/abp.2014_1862

Mapping of the influenza A hemagglutinin serotypes evolution by the ISSCOR method.

Jan P Radomski Interdisciplinary Center for Mathematical and Computational Modeling, Warsaw University, Warsaw, Poland and Institute of Biotechnology and Antibiotics, Warsaw, Poland.;
Piotr P Słonimski Centre de Génétique Moléculaire du CNRS & Université Pierre-et-Marie Curie, Paris, Gif sur Yvette, France.;
Włodzimierz Zagórski-Ostoja Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.;
Piotr Borowicz Institute of Biotechnology and Antibiotics, Warsaw, Poland.;

DOI: https://doi.org/10.18388/abp.2014_1862

Abstract

Analyses and visualizations by the ISSCOR method of influenza virus hemagglutinin genes of different A-subtypes revealed some rather striking temporal relationships between groups of individual gene subsets. Based on these findings we consider application of the ISSCOR-PCA method for analyses of large sets of homologous genes to be a worthwhile addition to a toolbox of genomics--allowing for a rapid diagnostics of trends, and ultimately even aiding an early warning of newly emerging epidemiological threats.

Published

2014-09-12

Issue

Vol. 61 No. 3 (2014): Influenza virus

Section

Articles

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