Leonurus cardiaca L. herb--a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis.

Bartłomiej Micota; Beata Sadowska; Anna Podsędek; Małgorzata Redzynia; Barbara Różalska

doi:10.18388/abp.2014_1911

Leonurus cardiaca L. herb--a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis.

Bartłomiej Micota Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Łódź, Poland.;
Beata Sadowska Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Łódź, Poland.;
Anna Podsędek Institute of Technical Biochemistry, Department of Biotechnology and Food Sciences Lodz Technical University, Poland, Łódź, Poland.;
Małgorzata Redzynia Institute of Technical Biochemistry, Department of Biotechnology and Food Sciences Lodz Technical University, Poland, Łódź, Poland.;
Barbara Różalska Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Łódź, Poland.;

DOI: https://doi.org/10.18388/abp.2014_1911

Abstract

The objective was an assessment of the impact of Leonurus cardiaca L. extract (LCE) and ursolic acid (UA) on the adhesive properties of Staphylococus aureus NCTC 8325 strain, expressing virulence factors important in the pathogenesis of infective endocarditis. The adhesion and biofilm formation of bacteria cultured in the presence of subinhibitory concentrations of LCE or UA on the abiotic surface or covered with fibrinogen, fibronectin or collagen, were evaluated. Inhibitory effects of LCE and UA on staphylococcal adherence to both types of surface were demonstrated. This, in the case of UA, resulted in a significant reduction of biofilm formation.

Published

2014-06-11

Issue

Vol. 61 No. 2 (2014)

Section

Articles

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