The amide of galacturonic acid with lysine as an immunodominant component of the lipopolysaccharide core region from Proteus penneri 42 strain.

Agata Palusiak; Anna Maciejewska; Czesław Ługowski; Antoni Różalski

doi:10.18388/abp.2014_1934

The amide of galacturonic acid with lysine as an immunodominant component of the lipopolysaccharide core region from Proteus penneri 42 strain.

Agata Palusiak Department of General Microbiology, Institute of Microbiology, Biotechnology and Immunology, University of Łódź, Łódź, Poland.;
Anna Maciejewska Department of Immunochemistry, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.;
Czesław Ługowski Department of Immunochemistry, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland amd Department of Biotechnology and Molecular Biology, University of Opole, Opole, Poland.;
Antoni Różalski Department of Immunobiology of Bacteria, Institute of Microbiology, Biotechnology and Immunology, University of Łódź, Łódź, Poland.;

DOI: https://doi.org/10.18388/abp.2014_1934

Abstract

Most Proteus lipopolysaccharides (LPSs) contain uronic acids or their amides with different amino acids, which together with other negatively charged components account for the acidic character of such LPS molecules. Previous studies have shown the significance of an amide of galacturonic acid with lysine [D-GalA(L-Lys)] for serological specificity of O-antigens from few P. mirabilis strains. In this work, the immunodominant role of GalALys was indicated for the P. penneri 42 LPS core region. The studies also showed the serological identity of core oligosaccharides from P. penneri 42 (O71), P. mirabilis 51/57 (O28) and R14/S1959 strains.

Published

2014-03-19

Issue

Vol. 61 No. 1 (2014)

Section

Articles

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