Frequencies of HLA-DQ2 and HLA-DQ8 haplotypes in Czech and Slovak coeliac patients and the healthy population.

Katerina Wroblova; Michal Kolorz; Igor Pav; Zuzana Horakova; Petra Filipova; Milan Bartos; Ladislava Bartosova

doi:10.18388/abp.2014_1943

Frequencies of HLA-DQ2 and HLA-DQ8 haplotypes in Czech and Slovak coeliac patients and the healthy population.

Katerina Wroblova Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic.;
Michal Kolorz Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic.;
Igor Pav Gastroenterological Clinic SMU and University Hospital in Bratislava-Petrzalka, Bratislava, Slovak Republic.;
Zuzana Horakova Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic.;
Petra Filipova Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic.;
Milan Bartos Department of Natural Drugs, UVPS Brno, Brno, Czech Republic.;
Ladislava Bartosova Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic.;

DOI: https://doi.org/10.18388/abp.2014_1943

Abstract

Coeliac disease is an autoimmune disorder with genetic predisposition. The aim was to determine the frequency of HLA-DQ2 and HLA-DQ8 in Czech and Slovak patients and the healthy population. The study included 127 patients and 66 healthy volunteers. HLA-DQ2 was identified in 85.03% patients, and 24.24% healthy individuals (P=0.0001; OR17.7632; CI=8.4347-37.4088). HLA-DQ8 was identified in 11.81% patients and 15.5% healthy individuals. HLA-DQ8 occurred more often in HLA-DQ2-negative patients compared to HLA-DQ2-positive patients (P=0.0494; OR3.5; CI 1.0428-11.7468). At least one of the studied HLA-variants was found more often in patients than in healthy individuals (P=0.0001; OR58.8; CI 7.6856-449.8602).

Published

2014-03-22

Issue

Vol. 61 No. 1 (2014)

Section

Articles

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