The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line.

Andrzej Łazarenkow; Marta Michalska; Anna Gorąca; Marek Mirowski; Jolanta Nawrot-Modranka; Aleksandra Piechota-Polanczyk

doi:10.18388/abp.2013_1981

The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line.

Andrzej Łazarenkow Department of Bioinorganic Chemistry, Faculty of Pharmacy, Medical University of Lodz, Łódź, Poland.;
Marta Michalska
Anna Gorąca
Marek Mirowski
Jolanta Nawrot-Modranka
Aleksandra Piechota-Polanczyk

DOI: https://doi.org/10.18388/abp.2013_1981

Abstract

Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in the HL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0%).

Published

2013-06-13

Issue

Vol. 60 No. 2 (2013)

Section

Articles

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