Adipokines and parameters of peritoneal membrane transport in newly started peritoneal dialysis patients.

Edyta Golembiewska; Krzysztof Safranow; Kazimierz Ciechanowski; Joanna Bober; Anna Bogacka; Joanna Stepniewska

doi:10.18388/abp.2013_2030

Edyta Golembiewska Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.;
Krzysztof Safranow Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.;
Kazimierz Ciechanowski Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.;
Joanna Bober Department of Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.;
Anna Bogacka Department of Human Nutrition, West Pomeranian University of Technology, Szczecin, Poland.;
Joanna Stepniewska Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.;

DOI: https://doi.org/10.18388/abp.2013_2030

Abstract

Adiponectin and leptin are two adipokines playing important roles in the regulation of body weight, appetite, carbohydrate and lipid metabolism. In patients with chronic kidney disease (CKD) adipokines accumulate in serum due to reduced renal clearance. Since adipokines have pleiotropic actions, the adipokine balance may have an impact on peritoneal membrane transport. The aim of this study was to assess whether serum adiponectin and leptin levels were related to peritoneal transport and residual renal function (RRF) in newly started peritoneal dialysis patients. 25 clinically stable patients, 4 to 6 weeks after the onset of PD, were included in the study. For each patient clinical and laboratory data were reviewed and standard PET test was performed. Serum adiponectin and leptin concentrations were determined and leptin/adiponectin (L/A) ratio was calculated. Serum adiponectin correlated negatively with weight, BMI and glucose concentration. Serum leptin and L/A ratio correlated positively with BMI. Serum adiponectin correlated positively with dialysate to plasma (D/P) creatinine ratio and ultrafiltration in PET test. Serum leptin level and L/A ratio correlated strongly negatively with peritoneal creatinine clearance. Serum adiponectin concentration is positively associated with baseline solute transport. Leptin concentration and L/A ratio are negatively associated with dialysis adequacy in newly started PD patients.