Poly(acrylic acid-co-methyl methacrylate)/metronidazole systems: synthesis and complexation.

Katarzyna Bialik-Wąs; Krzysztof Pielichowski

doi:10.18388/abp.2013_2068

Poly(acrylic acid-co-methyl methacrylate)/metronidazole systems: synthesis and complexation.

Katarzyna Bialik-Wąs Department of Chemistry and Technology of Polymers, Cracow University of Technology, Kraków, Poland.;
Krzysztof Pielichowski Department of Chemistry and Technology of Polymers, Cracow University of Technology, Kraków, Poland.;

DOI: https://doi.org/10.18388/abp.2013_2068

Abstract

We report on preparation of poly(acrylic acid-co-methyl methacrylate) (PAM) micro- and nanoparticles and, in the subsequent stage, complexation reaction with the active substance - metronidazole (MET). The drug release behavior of MET - loaded PAM micro- and nanoparticles was evaluated in water and phosphate buffered saline (PBS, 0.9% NaCl) at 37ºC. It has been found that introduction of MET into PAM micro- and nanoparticles enabled gradual and controlled release of the active substance. Structural analysis using FT-IR (ATR) and (1)H NMR, as well as surface morphology assessment by SEM, were performed.

Issue

Vol. 60 No. 4 (2013)

Section

Articles

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