Triterpenoid α-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage.

Edyta Biskup; Marek Gołębiowski; Robert Gniadecki; Piotr Stepnowski; Ewa Łojkowska

doi:10.18388/abp.2012_2147

Triterpenoid α-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage.

Edyta Biskup Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark. edyta.biskup@gmail.com;
Marek Gołębiowski
Robert Gniadecki
Piotr Stepnowski
Ewa Łojkowska

DOI: https://doi.org/10.18388/abp.2012_2147

Abstract

Rhaponticum carthamoides plants ("maral root") are widely used in Siberian folk medicine. The present study reports for the first time the presence of pentacyclic terpenoid, α-amyrin, in methanol extract from leaves of this plant. α-Amyrin induced proliferation of human keratinocytes (HaCaT) by about 18% while other extract components were ineffective. A panel of biochemical and cell-based assays testing the antioxidative and cytoprotective activites of α-amyrin indicated no antioxidative activity of this compound. α-Amyrin did not protect HaCaT cells against the damage caused by UVB radiation.

Published

2012-05-11

Issue

Vol. 59 No. 2 (2012)

Section

Articles

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