Synthesis of carotenoid-cysteine conjugates.

Afshin Zand; Attila Agócs; József Deli; Veronika Nagy

doi:10.18388/abp.2012_2193

Synthesis of carotenoid-cysteine conjugates.

Afshin Zand Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Hungary.;
Attila Agócs
József Deli
Veronika Nagy

DOI: https://doi.org/10.18388/abp.2012_2193

Abstract

Isozeaxanthin under acidic conditions forms an allylic cation which reacts readily with thiol nucleophiles. With N-acetylcysteine as a nucleophile the products obtained are carotenoid-cysteine conjugates in which the amino acid moiety is attached to the carotenoid via sulphur in position 4. The water solubility of the products can be increased by deprotection of the amino group. The antioxidant activity of the products were examined on human liver cells under conditions of hydrogen-peroxide induced oxidative stress.

Published

2012-03-17

Issue

Vol. 59 No. 1 (2012)

Section

Articles

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