In vitro effects of compounds isolated from Sideritis brevibracteata on bovine kidney cortex glutathione reductase.

Berivan Tandogan; Ayşegül Güvenç; İhsan Çalış; Nuriye Nuray Ulusu

doi:10.18388/abp.2011_2213

In vitro effects of compounds isolated from Sideritis brevibracteata on bovine kidney cortex glutathione reductase.

Berivan Tandogan Department of Biochemistry, Hacettepe University, Ankara, Turkey.;
Ayşegül Güvenç
İhsan Çalış
Nuriye Nuray Ulusu

DOI: https://doi.org/10.18388/abp.2011_2213

Abstract

Glutathione reductase (GR, E.C 1.6.4.2) is a flavoprotein that catalyzes NADPH-dependent reduction of oxidized glutathione (GSSG) to reduced glutathione (GSH). The aim of this study was to investigate in vitro effects of phenolic compounds isolated from Sideritis brevibracteata on bovine kidney GR. The Sideritis species are widely found in nature and commonly used as medicinal plants. 7-O-glycosides of 8-OH-flavones (hypolaetin, isoscutellarein and 3'-hydroxy-4'-O-methylisoscutellarein) were isolated from aerial parts of Sideritis brevibracteata. These compounds inhibited bovine kidney cortex GR in a concentration-dependent manner. Kinetic characterization of the inhibition was also performed.

Published

2011-12-06

Issue

Vol. 58 No. 4 (2011)

Section

Articles

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