Lower  levels  of  Caveolin-1  and  higher  levels  of  endothelial  nitric   oxide  synthase  are  observed  in  abdominal  aortic  aneurysm   patients  treated  with  simvastatin

Karolina Kowalska; Dominika E Habrowska-Górczyńska; Christoph Neumayer; Michael Bolliger; Christoph Domenig; Agnieszka W Piastowska-Ciesielska; Ihor Huk; Aleksandra Piechota-Polanczyk

doi:10.18388/abp.2017_2305

Karolina Kowalska Department of Surgery, Division of Vascular Surgery, Medical University of Vienna, Vienna, Austria, Laboratory of Cell Cultures and Genomic Analysis, Department of Comparative Endocrinology, Medical University of Lodz, Łódź, Poland
Dominika E Habrowska-Górczyńska Laboratory of Cell Cultures and Genomic Analysis, Department of Comparative Endocrinology, Medical University of Lodz, Łódź, Poland
Christoph Neumayer Department of Surgery, Division of Vascular Surgery, Medical University of Vienna, Vienna, Austria
Michael Bolliger Department of Surgery, Division of Vascular Surgery, Medical University of Vienna, Vienna, Austria
Christoph Domenig Department of Surgery, Division of Vascular Surgery, Medical University of Vienna, Vienna, Austria
Agnieszka W Piastowska-Ciesielska Laboratory of Cell Cultures and Genomic Analysis, Department of Comparative Endocrinology, Medical University of Lodz, Łódź, Poland
Ihor Huk Department of Surgery, Division of Vascular Surgery, Medical University of Vienna, Vienna, Austria
Aleksandra Piechota-Polanczyk Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland

DOI: https://doi.org/10.18388/abp.2017_2305

Keywords: Cav-1, eNOS, abdominal aortic aneurysm, simvastatin

Abstract

This study was undertaken to verify if simvastatin modulates Cav-1/eNOS expression and if this modulation is associated with changes in pro- and anti-inflammatory cytokines and Toll-like receptor 4 (TLR4) in abdominal aortic aneurysm (AAA). It was 1:2 case-control study of non-statin (n=12) and simvastatin-treated patients (n=24) who underwent open AAA repair. Simvastatin treatment significantly and dose-dependently decreased Cav-1 and increased eNOS expression in AAA wall (p<0.05 and p<0.01, respectively). The changes in Cav-1 and eNOS were associated with a trend towards decreased concentration of IL-6 and IL-17 (p>0.05) and increased concentration of IL-10 (p=0.055) but not with TLR4 expression suggesting other mechanism of simvastatin influence on Cav-1 and eNOS in AAA wall. Simvastatin may modulate Cav-1 and eNOS expression in aneurysmal wall indicating a new beneficial role of statins in AAA patients.

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