Tips for optimizing organ preservation solutions

Aneta Ostróżka-Cieślik; Barbara Dolińska; Florian Ryszka

doi:10.18388/abp.2017_2312

Aneta Ostróżka-Cieślik Department of Pharmaceutical Technology, Chair of Applied Pharmacy, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland
Barbara Dolińska Department of Pharmaceutical Technology, Chair of Applied Pharmacy, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland “Biochefa” Pharmaceutical Research and Production Plant, Sosnowiec, Poland
Florian Ryszka “Biochefa” Pharmaceutical Research and Production Plant, Sosnowiec, Poland

DOI: https://doi.org/10.18388/abp.2017_2312

Keywords: organ transplantation, preservation solution, hormones, micronutrients

Abstract

Organ injury during ischemia is one of the clinical problems of today's transplantation. It occurs during warm ischemia time (WIT) when the blood flow is cut off and during cold ischemia when a graft is chilled in situ until the circulation is restored to the recipient organism. Fast cooling of the organ slows metabolism and activates intracellular enzymes, which minimizes the effects of warm ischemia. Unfortunately, hypothermia also results in inhibition of ATP synthesis, cell swelling and intracellular acidity. That is why research is continually being conducted to develop new fluids for rinsing and storing organs as well as to optimize the composition of those that are already in use, which will allow for longer and more effective graft storage and restoration of its optimal functions after transplantation. The article provides current information on rinsing and storage fluids available on the global market. It also discusses the directions of fluid modification with hormones and micronutrients.