Physicochemical properties and cytotoxicity of hydrogels based on Beetosan® containing sage and bee pollen

Bożena Tyliszczak; Anna Drabczyk; Sonia Kudłacik-Kramarczyk; Beata Grabowska; Magdalena Kędzierska

doi:10.18388/abp.2017_2319

Bożena Tyliszczak Cracow University of Technology
Anna Drabczyk Cracow University of Technology
Sonia Kudłacik-Kramarczyk Cracow University of Technology
Beata Grabowska AGH University of Science and Technology in Kraków
Magdalena Kędzierska Medical University of Lodz

DOI: https://doi.org/10.18388/abp.2017_2319

Keywords: hydrogels, cytotoxicity, fibroblasts, chitosan, sage, wettability

Abstract

Currently, more and more attention is being paid to issues related to the environmental protection, waste management as well as to the development of polymers with useful properties. Therefore, present research involved preparation of hydrogels the main component of which was Beetosan^® - chitosan derived from the multi-stage processing of died bees. Moreover, hydrogels were additionally modified with natural substances. Based on the research it can be stated that such combination of Beetosan^® hydrogel matrix and mentioned additives resulted in a preparation of polymers characterized by negative impact on cancer cells. Finally, it can be concluded that the use of natural-derived reagents and synthesis of polymers using these reagents (as a result of environmentally friendly photopolymerization) lead to the receipt of the materials with unusual properties, with particular emphasis on antitumor activity.

Author Biographies

Bożena Tyliszczak, Cracow University of Technology

Department of Chemistry and Technology of Polymers

Anna Drabczyk, Cracow University of Technology

Institute of Inorganic Chemistry and Technology

Sonia Kudłacik-Kramarczyk, Cracow University of Technology

Institute of Inorganic Chemistry and Technology

Beata Grabowska, AGH University of Science and Technology in Kraków

Faculty of Foundry Engineering

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