Role of Apolipoprotein E gene polymorphism in the risk of familial hypercholesterolemia: a case-control study

Turky H Almigbal; Mohammed Ali Batais; Rana M Hasanato; Fawaziah Khalaf Alharbi; Imran Ali Khan; Khalid Khalaf Alharbi

doi:10.18388/abp.2017_2344

Turky H Almigbal Department of Family and Community Medicine, King Saud University, Riyadh, Saudi Arabia.
Mohammed Ali Batais Department of Family and Community Medicine, King Saud University, Riyadh, Saudi Arabia.
Rana M Hasanato Department of Pathology College of Medicine and University Hospitals, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Fawaziah Khalaf Alharbi Department of Biology Science, College of Science and Arts, Al-Qassim University, Al-Qassim, Saudi Arabia.
Imran Ali Khan Dr. Imran Ali Khan Mohammed Research Scientist Clinical Laboratory Sciences Department College of Applied Medical Sciences King Saud University Riyadh-11433 Kingdom of Saudi Arabia
Khalid Khalaf Alharbi Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, PO Box-10219, Riyadh-11433, Kingdom of Saudi Arabia.

DOI: https://doi.org/10.18388/abp.2017_2344

Abstract

Familial Hypercholesterolemia (FH) is characterized by elevated cholesterol; this is based on biochemical, clinical, and genetic studies and FH disease, which was documented even with limited mutations. Earlier studies were associated with Apolipoprotein E (ApoE) in variable diseases. The current study aims to investigate the genetic association between FH disease and ApoE gene (rs429358 and rs7412) in the Saudi population. This study has been carried out as a case-control and is a hospital-based study in Saudi Arabia. Two hundred and four subjects were recruited as FH participants (n=104) and the others as controls (n=100). Common polymorphisms (rs429358 and rs7412) were selected from the ApoE gene and we then performed the genotyping as the TaqMan assay. Moreover, the ApoE risk allele E4 is significantly associated in FH cases and controls (OR-2.24 (95%CI: 1.06-4.70); p=0.02). Lipid profile parameters were significantly associated (p<0.05); however, a combination of ApoE alleles and lipid profiles could not find a correlation (p>0.05). The FH case-control study was associated with the E4 allele in the Saudi population. The risk of allele E4 which is a reliable marker for lipid profiles, but did not correlate with ApoE alleles.

Author Biographies

Turky H Almigbal, Department of Family and Community Medicine, King Saud University, Riyadh, Saudi Arabia.

Assistant Professor

Mohammed Ali Batais, Department of Family and Community Medicine, King Saud University, Riyadh, Saudi Arabia.

Assistant Professor

Rana M Hasanato, Department of Pathology College of Medicine and University Hospitals, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Associate Professor

Fawaziah Khalaf Alharbi, Department of Biology Science, College of Science and Arts, Al-Qassim University, Al-Qassim, Saudi Arabia.

Assistant Professor

Imran Ali Khan, Dr. Imran Ali Khan Mohammed Research Scientist Clinical Laboratory Sciences Department College of Applied Medical Sciences King Saud University Riyadh-11433 Kingdom of Saudi Arabia

Assistant Professor

Khalid Khalaf Alharbi, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, PO Box-10219, Riyadh-11433, Kingdom of Saudi Arabia.

Professor

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