Lack of correlation between X region spa polymorphism and virulence of methicillin resistant and methicillin sensitive Staphylococcus aureus strains.

Julianna Kurlenda; Mariusz Grinholc; Piotr Szweda

doi:10.18388/abp.2010_2385

Lack of correlation between X region spa polymorphism and virulence of methicillin resistant and methicillin sensitive Staphylococcus aureus strains.

Julianna Kurlenda Department of Clinical Bacteriology in Provincial Hospital, Koszalin, Poland. bakteriologia@op.pl;
Mariusz Grinholc
Piotr Szweda

DOI: https://doi.org/10.18388/abp.2010_2385

Abstract

Staphylococcus aureus is an etiological factor of severe infections in both hospital and ambulatory environments. As methicillin resistant Staphylococcus aureus strains spread quickly across healthcare centers resulting in life-threatening infections with increased mortality, they are considered more virulent than MSSA strains. Protein A, encoded by the spa gene, is one of the virulence factors involved in the staphylococcal pathogenesis. It has been suggested that the number of 24-bp tandem repeat units along the X region of the spa gene correlates with the virulence level of the strains. The current work analyzed the relationships between the virulence of MRSA and MSSA strains with region X polymorphism. No obvious correlation was observed.

Published

2010-03-22

Issue

Vol. 57 No. 1 (2010)

Section

Articles

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