"MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats.

Fernanda M Ferreira; Francisco Peixoto; Elsa Nunes; Cristina Sena; Raquel Seiça; Maria Sancha Santos

doi:10.18388/abp.2010_2424

"MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats.

Fernanda M Ferreira Department of Environment, Agricultural College of Coimbra - Polytechnic Institute of Coimbra, Bencanta, Portugal. fmlferreira@gmail.com;
Francisco Peixoto
Elsa Nunes
Cristina Sena
Raquel Seiça
Maria Sancha Santos

DOI: https://doi.org/10.18388/abp.2010_2424

Abstract

Several chemical compounds found in plant products have proven to possess beneficial properties, being currently pointed out due to their pharmacological potential in type 2 diabetes mellitus complications. In this context, we studied the effect of Geranium robertianum L. (herb Robert) leaf decoctions in Goto-Kakizaki (GK) rats, a model of type 2 diabetes. Our results showed that oral administration of G. robertianum leaf decoctions over a period of four weeks lowered the plasma glucose levels in diabetic rats. Furthermore, the treatment with G. robertianum extracts improved liver mitochondrial respiratory parameters (state 3, state 4 and FCCP-stimulated respiration) and increased oxidative phosphorylation efficiency.

Published

2010-11-01

Issue

Vol. 57 No. 4 (2010)

Section

Articles

Acta Biochimica Polonica is an OpenAccess quarterly and publishes four issues a year. All contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.