Identification of a novel protein encoded by third conserved gene within RAG locus.

Monika Kasztura; Arkadiusz Miazek; Małgorzata Cebrat; Paweł Kisielow

doi:10.18388/abp.2009_2530

Identification of a novel protein encoded by third conserved gene within RAG locus.

Monika Kasztura Laboratory of Transgenesis and Lymphocyte Biology, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.;
Arkadiusz Miazek
Małgorzata Cebrat
Paweł Kisielow

DOI: https://doi.org/10.18388/abp.2009_2530

Abstract

Recently, a third evolutionarily conserved gene, NWC, was discovered within the recombination activating gene (RAG) locus, known to contain the RAG1 and RAG2 genes. Here, we identify and characterize the murine endogenous NWC protein which has no homology to any known protein and is ubiquitously expressed. In the cell, the NWC protein which has been suggested to function as a transcriptional repressor, is found in the cytoplasm as well as in the nucleus.

Published

2009-03-17

Issue

Vol. 56 No. 1 (2009)

Section

Articles

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