NLC as a potential carrier system for transdermal delivery of forskolin*:

Elwira Lasoń; Elżbieta Sikora; Małgorzata Miastkowska; Elvira Escribano; Maria Jose Garcia-Celma; Conxita Solans; Meritxell Llinas; Jan Ogonowski

doi:10.18388/abp.2018_2554

Elwira Lasoń Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology
Elżbieta Sikora Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology
Małgorzata Miastkowska Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology
Elvira Escribano Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Barcelona
Maria Jose Garcia-Celma Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Barcelona
Conxita Solans Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Chemical and Biomolecular Nanotechnology, Barcelona
Meritxell Llinas Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Chemical and Biomolecular Nanotechnology, Barcelona
Jan Ogonowski Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology

DOI: https://doi.org/10.18388/abp.2018_2554

Abstract

NLC (nanostructured lipid carriers), composed with substances of GRAS (generally recognized as safe) status, were obtained by using the hot high pressure homogenization technique (HPH). The influence of number of homogenization cycles and concentration of a surfactant (decyl glucoside) on NLC properties were studied. The systems stability was assessed by macroscopic observation, light backscattering and zeta potential measurements. NLC particle size was measured by means of dynamic light scattering (DLS). The kinetically stable formulations were loaded with forskolin and selected for in vitro drug permeation study (Franz cell method). The concentration of forskolin in the receptor solution (i.e. Ethanol/PBS mixture) was analyzed by high performance liquid chromatography (HPLC) with UV detection. The obtained results have shown that NLC formulations could be used as effective carriers for forskolin permeation through the skin.

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NLC as a potential carrier system for transdermal delivery of forskolin*

* Preliminary report presented at 6th Central European Congress of Life Sciences. EUROBIOTECH, 11–14 September, 2017. Kraków, Poland

Abstract

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