Lactose intolerance, lactose malabsorption and genetic predisposition to adult-type hypolactasia in patients after restorative proctocolectomy

Jarosław Walkowiak; Ewa Fidler-Witoń; Aleksandra Glapa; Jacek Paszkowski; Maciej Borejsza-Wysocki; Anna Miśkiewicz-Chotnicka; Tomasz Banasiewicz; Aleksandra Lisowska

doi:10.18388/abp.2018_2730

Jarosław Walkowiak Poznań University of Medical Sciences, Department of Paediatric Gastroenterology and Metabolic Diseases, Poznań, Poland https://orcid.org/0000-0001-5813-5707
Ewa Fidler-Witoń Poznań University of Medical Sciences, Department of Paediatric Gastroenterology and Metabolic Diseases, Poznań, Poland https://orcid.org/0000-0003-0081-1383
Aleksandra Glapa Poznań University of Medical Sciences, Department of Paediatric Gastroenterology and Metabolic Diseases, Poznań, Poland https://orcid.org/0000-0002-3017-0524
Jacek Paszkowski Poznań University of Medical Sciences, Chair and Department of General & Endocrine Surgery, and Gastroenterological Oncology, Poznań, Poland
Maciej Borejsza-Wysocki Poznań University of Medical Sciences, Chair and Department of General & Endocrine Surgery, and Gastroenterological Oncology, Poznań, Poland
Anna Miśkiewicz-Chotnicka Poznań University of Medical Sciences, Department of Paediatric Gastroenterology and Metabolic Diseases, Poznań, Poland
Tomasz Banasiewicz Poznań University of Medical Sciences, Chair and Department of General & Endocrine Surgery, and Gastroenterological Oncology, Poznań, Poland
Aleksandra Lisowska Poznań University of Medical Sciences, Department of Paediatric Gastroenterology and Metabolic Diseases, Poznań, Poland

DOI: https://doi.org/10.18388/abp.2018_2730

Abstract

This study provides up-to-date findings on lactose malabsorption, lactose intolerance and genetic predisposition to adult-type hypolactasia in 72 patients after restorative proctocolectomy (RPC). The lactose malabsorption was assessed by hydrogen-methane breath test. Genetic predisposition to adult-type hypolactasia was assessed by detecting –13910T/C polymorphism in the lactase gene. Lactose intolerance was more frequent in UC (ulcerative colitis) patients than FAP (familial adenomatous polyposis) patients (77.5% vs. 55.2%; p=0.01). The C/C genotype of the lactase gene was observed in 39.1% subjects with no significant difference between UC and FAP patients. Lactose malabsorption occurred in 10.1% of subjects and almost only in patients with genetic predisposition, with the same frequency in UC and FAP patients.