Fluorescence of the tri-cyclic adenine and isoguanine derivatives and their ribosides: possible analytical applications

Alicja Stachelska-Wierzchowska; Jacek Wierzchowski

doi:10.18388/abp.2019_2885

Fluorescence of the tri-cyclic adenine and isoguanine derivatives and their ribosides: possible analytical applications

Alicja Stachelska-Wierzchowska Department of Physics and Biophysics, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland https://orcid.org/0000-0001-7744-7917
Jacek Wierzchowski Department of Physics and Biophysics, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland https://orcid.org/0000-0002-7552-8630

DOI: https://doi.org/10.18388/abp.2019_2885

Abstract

Fluorescent tri-cyclic purine analogs, derivatives of isoguanine and adenine, were examined as potential substrates of purine-nucleoside phosphorylase. It was found previously that etheno- derivatives of both compounds are ribosylated in phosphate-free media, but ribosylation places in some instances differ from purine N9. New ribosides are examined as potential substrates of human blood PNP and indicators of this enzyme. Of these, N6-riboside of 1,N6-etheno-adenine was found the most promising.

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Published

2019-12-05

Issue

Vol. 66 No. 4 (2019): Part I and Part II - FEBS

Section

FEBS 2019

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