Identification of 2-[2-nitro-4-(trifluoromethyl)benzoyl]- cyclohexane-1,3-dione metabolites in urine of patients suffering from tyrosinemia type I with the use of 1H and 19F NMR spectroscopy.

Przemysław Szczeciński; Diana Lamparska; Adam Gryff-Keller; Wanda Gradowska

doi:10.18388/abp.2008_3036

Identification of 2-[2-nitro-4-(trifluoromethyl)benzoyl]- cyclohexane-1,3-dione metabolites in urine of patients suffering from tyrosinemia type I with the use of 1H and 19F NMR spectroscopy.

Przemysław Szczeciński Faculty of Chemistry, Warsaw University of Technology, Warszawa, Poland. przemsz@ch.pw.edu.pl;
Diana Lamparska
Adam Gryff-Keller
Wanda Gradowska

DOI: https://doi.org/10.18388/abp.2008_3036

Abstract

Organic extracts of six urine samples from children treated with nitisinone, a medicine against tyrosinemia type I, were investigated by (1)H and (19)F NMR spectroscopy. The presence of unchanged 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC), 6-hydroxy-2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC-OH) and 2-nitro-4-trifluoromethylbenzoic acid (NTFA) as well as a few other unidentified compounds containing CF(3) group was documented.

Published

2008-11-28

Issue

Vol. 55 No. 4 (2008)

Section

Articles

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