Photodynamic effect of lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus.

Agata Jurczak; Bozena Szramka; Mariusz Grinholc; Janina Legendziewicz; Krzysztof P Bielawski

doi:10.18388/abp.2008_3064

Photodynamic effect of lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus.

Agata Jurczak Department of Biotechnology, Intercollegiate Faculty of Biotechnology, Division of Molecular Diagnostics, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland.;
Bozena Szramka
Mariusz Grinholc
Janina Legendziewicz
Krzysztof P Bielawski

DOI: https://doi.org/10.18388/abp.2008_3064

Abstract

Photodynamic therapy (PDT), used for cancer treatment, is also an alternative method for eradication of drug-resistant bacteria. This method utilizes a nontoxic light-activated dye, called a photosensitizer, and visible light to produce reactive oxygen species that lead to bacterial cell death. The purpose of this study was to investigate the bactericidal effect of PDT using lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus strains. The new photosensitizers appeared to be photodynamically ineffective. No enhancement of antistaphylococcal activity of TMPyP was observed after the conjugation of the porphyrin with lanthanide ions. Additionally, a significant difference in the susceptibility of two bacterial strains to unmodified TMPyP was observed.

Published

2008-08-25

Issue

Vol. 55 No. 3 (2008)

Section

Articles

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