Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.

Joanna Krwawicz; Katarzyna D Arczewska; Elzbieta Speina; Agnieszka Maciejewska; Elzbieta Grzesiuk

doi:10.18388/abp.2007_3219

Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.

Joanna Krwawicz Department of Molecular Biology, Institute of Biochemistry and Biophysics Polish Academy of Sciences, Warszawa, Poland. asiak@ibb.waw.pl;
Katarzyna D Arczewska
Elzbieta Speina
Agnieszka Maciejewska
Elzbieta Grzesiuk

DOI: https://doi.org/10.18388/abp.2007_3219

Abstract

Base excision repair (BER) pathway executed by a complex network of proteins is the major system responsible for the removal of damaged DNA bases and repair of DNA single strand breaks (SSBs) generated by environmental agents, such as certain cancer therapies, or arising spontaneously during cellular metabolism. Both modified DNA bases and SSBs with ends other than 3'-OH and 5'-P are repaired either by replacement of a single or of more nucleotides in the processes called short-patch BER (SP-BER) or long-patch BER (LP-BER), respectively. In contrast to Escherichia coli cells, in human ones, the two BER sub-pathways are operated by different sets of proteins. In this review the selection between SP- and LP-BER and mutations in BER and end-processors genes and their contribution to bacterial mutagenesis and human diseases are considered.

Published

2007-09-24

Issue

Vol. 54 No. 3 (2007)

Section

Articles

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