Oxidative damage to DNA and antioxidant status in aging and age-related diseases.

Ryszard Olinski; Agnieszka Siomek; Rafal Rozalski; Daniel Gackowski; Marek Foksinski; Jolanta Guz; Tomasz Dziaman; Anna Szpila; Barbara Tudek

doi:10.18388/abp.2007_3265

Oxidative damage to DNA and antioxidant status in aging and age-related diseases.

Ryszard Olinski Department of Clinical Biochemistry, Collegium Medicum in Bydgoszcz, Poland. ryszardo@cm.umk.pl;
Agnieszka Siomek
Rafal Rozalski
Daniel Gackowski
Marek Foksinski
Jolanta Guz
Tomasz Dziaman
Anna Szpila
Barbara Tudek

DOI: https://doi.org/10.18388/abp.2007_3265

Abstract

Aging is a complex process involving morphologic and biochemical changes in single cells and in the whole organism. One of the most popular explanations of how aging occurs at the molecular level is the oxidative stress hypothesis. Oxidative stress leads in many cases to an age-dependent increase in the cellular level of oxidatively modified macromolecules including DNA, and it is this increase which has been linked to various pathological conditions, such as aging, carcinogenesis, neurodegenerative and cardiovascular diseases. It is, however, possible that a number of short-comings associated with gaps in our knowledge may be responsible for the failure to produce definite results when applied to understanding the role of DNA damage in aging and age-related diseases.

Published

2007-01-09

Issue

Vol. 54 No. 1 (2007)

Section

Articles

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