Hypothesis: cell volume limits cell divisions.

Tomasz Biliński; Grzegorz Bartosz

doi:10.18388/abp.2006_3313

Hypothesis: cell volume limits cell divisions.

Tomasz Biliński Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland. bilinski@univ.rzezow.pl;
Grzegorz Bartosz

DOI: https://doi.org/10.18388/abp.2006_3313

Abstract

Mammalian somatic cells and also cells of the yeast Saccharomyces cerevisiae are capable of undergoing a limited number of divisions. Reaching the division limit is referred to, apparently not very fortunately, as replicative aging. A common feature of S. cerevisiae cells and fibroblasts approaching the limit of cell divisions in vitro is attaining giant volumes. In yeast cells this phenomenon is an inevitable consequence of budding so it is not causally related to aging. Therefore, reaching a critically large cell volume may underlie the limit of cell divisions. A similar phenomenon may limit the number of cell divisions of cultured mammalian cells. The term replicative (generative) aging may be therefore illegitimate.

Published

2006-11-14

Issue

Vol. 53 No. 4 (2006)

Section

Articles

Acta Biochimica Polonica is an OpenAccess quarterly and publishes four issues a year. All contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.