Synthesis, antimicrobial activity and structural studies of low molecular mass lysine dendrimers.

Jolanta Janiszewska; Zofia Urbańczyk-Lipkowska

doi:10.18388/abp.2006_3364

Synthesis, antimicrobial activity and structural studies of low molecular mass lysine dendrimers.

Jolanta Janiszewska Industrial Chemistry Research Institute, Warszawa, Poland.;
Zofia Urbańczyk-Lipkowska

DOI: https://doi.org/10.18388/abp.2006_3364

Abstract

Four low molecular mass lysine dendrimers were synthesized by Boc chemistry in solution (155 and 169) and Fmoc chemistry on solid support (P2 and P13). The structure and fragmentation mode of the above dendrimers was investigated in gas phase by the LSI-MS and ESI-MS techniques. (1)H and (13)C NMR analysis in solution (d(6)-DMSO) allowed to confirm the correct structure. Antimicrobial activities of the dendrimers against Staphylococcus aureus, Escherichia coli and Candida albicans confirmed our hypothesis that the dendrimer structure can be used for construction of molecules interacting with biological membranes.

Published

2006-02-23

Issue

Vol. 53 No. 1 (2006)

Section

Articles

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