Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic.

Maciej Baginski; Kamil Sternal; Jacek Czub; Edward Borowski

doi:10.18388/abp.2005_3426

Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic.

Maciej Baginski Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland. maciekb@hypnos.chem.pg.gda.pl;
Kamil Sternal
Jacek Czub
Edward Borowski

DOI: https://doi.org/10.18388/abp.2005_3426

Abstract

Amphotericin B (AmB) is a well known polyene macrolide antibiotic used to treat systemic fungal infections. Despite its toxicity AmB is still regarded as a life-saving drug. The lack of adequate knowledge of the AmB mechanism of action is a serious obstacle to efficient development of new less toxic derivatives. Complementary to various experimental approaches, computational chemistry methods were used to study AmB mechanism of action. A programme lasting for a decade, that was run by our group covered studies of: i) molecular properties of AmB and its membrane targets, ii) structure and properties of AmB membrane channels, and iii) interaction of AmB with the membrane.

Published

2005-08-05

Issue

Vol. 52 No. 3 (2005)

Section

Articles

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