Genetic models to study adult neurogenesis.

Robert K Filipkowski; Anna Kiryk; Anna Kowalczyk; Leszek Kaczmarek

doi:10.18388/abp.2005_3449

Genetic models to study adult neurogenesis.

Robert K Filipkowski Laboratory of Molecular Neurobiology, Department of Molecular and Cellular Neurobiology, Nencki Institute, Warszawa, Poland. r.filipkowski@nencki.gov.pl;
Anna Kiryk
Anna Kowalczyk
Leszek Kaczmarek

DOI: https://doi.org/10.18388/abp.2005_3449

Abstract

In the central nervous system (CNS) generation of new neurons continues throughout adulthood, when it is limited to the olfactory bulb and hippocampus. The knowledge regarding the function of newly-generated neurons remains limited and is vigorously investigated using diverse approaches. Among these are genetically modified mice, most of them of knock-out type (KO). Results from 23 diverse KO mouse models demonstrate the importance of particular proteins (growth factors, nitric oxide synthases, receptors, cyclins/cyclin-associated proteins, transcription factors, etc.) in adult neurogenesis (ANGE) as well as separate it from developmental neurogenesis. These results bring us closer to revealing the function of newly generated neurons in adult brains.

Published

2005-06-25

Issue

Vol. 52 No. 2 (2005)

Section

Articles

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