The level of endogenous DNA damage in lymphocytes isolated from blood is associated with the fluctuation of 17beta-estradiol concentration in the follicular phase of healthy young women.

Maria Kapiszewska; Malgorzata Kalemba; Aneta Grzesiak; Kinga Kocemba

doi:10.18388/abp.2005_3469

The level of endogenous DNA damage in lymphocytes isolated from blood is associated with the fluctuation of 17beta-estradiol concentration in the follicular phase of healthy young women.

Maria Kapiszewska Department of General Biochemistry, Faculty of Biotechnology, Jagiellonian University, Krakow, Poland. mkapisz@if.uj.edu.pl;
Malgorzata Kalemba
Aneta Grzesiak
Kinga Kocemba

DOI: https://doi.org/10.18388/abp.2005_3469

Abstract

The aim of this study was to evaluate whether the differences in plasma 17beta-estradiol concentration in early and late follicular phases of the menstrual cycle can affect the level of endogenous DNA damage in lymphocytes assessed by comet assay, and whether the extent of this damage in the follicular phase is associated with the genotype of catechol-O-methyltransferase (COMT). The level of DNA damage was positively correlated with 17beta-estradiol concentration only in the late follicular phase. Subjects with the COMT L/L homozygous mutated variant revealed more DNA damage as compared to individuals with the COMT wild-type and heterozygous (H/L+HH) genotype.

Published

2005-06-20

Issue

Vol. 52 No. 2 (2005)

Section

Articles

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