Bacterial chromosome segregation.

Aneta A Bartosik; Grazyna Jagura-Burdzy

doi:10.18388/abp.2005_3481

Bacterial chromosome segregation.

Aneta A Bartosik Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland. anetab2@ibb.waw.pl;
Grazyna Jagura-Burdzy

DOI: https://doi.org/10.18388/abp.2005_3481

Abstract

In most bacteria two vital processes of the cell cycle: DNA replication and chromosome segregation overlap temporally. The action of replication machinery in a fixed location in the cell leads to the duplication of oriC regions, their rapid separation to the opposite halves of the cell and the duplicated chromosomes gradually moving to the same locations prior to cell division. Numerous proteins are implicated in co-replicational DNA segregation and they will be characterized in this review. The proteins SeqA, SMC/MukB, MinCDE, MreB/Mbl, RacA, FtsK/SpoIIIE playing different roles in bacterial cells are also involved in chromosome segregation. The chromosomally encoded ParAB homologs of active partitioning proteins of low-copy number plasmids are also players, not always indispensable, in the segregation of bacterial chromosomes.

Published

2005-03-31

Issue

Vol. 52 No. 1 (2005)

Section

Articles

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