Monocytes in children with leukemias and lymphomas -- down-regulation of HLA and costimulatory molecules.

Włodzimierz Łuczyński; Anna Stasiak-Barmuta; Maryna Krawczuk-Rybak; Marcin Szymański; Iwona Malinowska; Małgorzata Mitura-Lesiuk

doi:10.18388/abp.2004_3540

Monocytes in children with leukemias and lymphomas -- down-regulation of HLA and costimulatory molecules.

Włodzimierz Łuczyński Department of Pediatric Oncology, Medical University of Białystok, Poland. vlodek@amb.edu.pl;
Anna Stasiak-Barmuta
Maryna Krawczuk-Rybak
Marcin Szymański
Iwona Malinowska
Małgorzata Mitura-Lesiuk

DOI: https://doi.org/10.18388/abp.2004_3540

Abstract

The aim of the study was to evaluate the function of monocytes in children with leukemias and lymphomas based on the expression of critical costimulatory, activatory and adhesion molecules (CD80, CD86, HLA-DR and CD54 = ICAM-1), estimated with tricolor flow cytometry. In comparison to the control group we found a lower percentage of monocytes with costimulatory molecules (CD80 before and CD86 after lipopolysaccharide stimulation) at the time of diagnosis and of monocytes with HLA-DR molecules after remission induction. We also noted a lower percentage of monocytes with HLA-DR expression in the group with severe or therapy resistant infections. The results of our investigation suggest some defect in costimulation and antigen presentation in lymphoproliferative diseases in children.

Published

2004-12-31

Issue

Vol. 51 No. 4 (2004)

Section

Articles

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