New analogue of cyclolinopeptide B modified by amphiphilic residue of alpha-hydroxymethylmethionine.

Renata Witkowska; Anna Donigiewicz; Michał Zimecki; Janusz Zabrocki

doi:10.18388/abp.2004_3597

New analogue of cyclolinopeptide B modified by amphiphilic residue of alpha-hydroxymethylmethionine.

Renata Witkowska Institute of Organic Chemistry, Technical University of Łódz, Łódz, Poland.;
Anna Donigiewicz
Michał Zimecki
Janusz Zabrocki

DOI: https://doi.org/10.18388/abp.2004_3597

Abstract

In order to evaluate the role and influence of the methionine residue on the biological activity of cyclolinopeptide B, an analogue with methionine residue in position 7 replaced by the amphiphilic (S)-alpha-hydroxymethylmethionine residue was synthesized. This peptide exhibits high immunosuppressive activity in the cellular, and to a lesser degree in the humoral immune response, comparable to that of CsA. In addition, the peptide was devoid of toxicity, even at high doses.

Published

2004-03-31

Issue

Vol. 51 No. 1 (2004)

Section

Articles

Acta Biochimica Polonica is an OpenAccess quarterly and publishes four issues a year. All contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.