Biological evaluation of analogues of an insect neuropeptide proctolin.

Iwona Woźnica; Wioletta Szeszel-Fedorowicz; Grzegorz Rosińskiand; Danuta Konopińska

doi:10.18388/abp.2004_3602

Biological evaluation of analogues of an insect neuropeptide proctolin.

Iwona Woźnica Faculty of Chemistry, University of Wrocław, Wrocław, Poland.;
Wioletta Szeszel-Fedorowicz
Grzegorz Rosińskiand
Danuta Konopińska

DOI: https://doi.org/10.18388/abp.2004_3602

Abstract

Continuing our studies on proctolin (Arg-Tyr-Leu-Pro-Thr) we performed the synthesis and biological evaluation of 52 analogues substituted in position 2, 3, 4, and 5 of the peptide chain. The peptides were bioassayed for cardiotropic activity in vitro on Tenebrio molitor and myotropic activity on foregut of Schistocerca gregaria. Twenty analogues retained 20-80% of proctolin activity.

Published

2004-03-31

Issue

Vol. 51 No. 1 (2004)

Section

Articles

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