Interaction of class A G protein-coupled receptors with G proteins.

Rafał Slusarz; Jerzy Ciarkowski

doi:10.18388/abp.2004_3604

Interaction of class A G protein-coupled receptors with G proteins.

Rafał Slusarz Faculty of Chemistry, University of Gdansk, Gdańsk, Poland.;
Jerzy Ciarkowski

DOI: https://doi.org/10.18388/abp.2004_3604

Abstract

A model for interaction of class A G protein-coupled receptor with the G protein G(alpha) subunit is proposed using the rhodopsin-transducin (RD/Gt) prototype. The model combines the resolved interactions/distances, essential in the active RD*/Gt system, with the structure of Gt(alpha) C-terminal peptide bound to RD* while stabilizing it. Assuming the interactions involve conserved parts of the partners, the model specifies the conserved Helix 2 non-polar X- - -X, Helix 3 DRY and Helix 7/8 NP- -Y- - F RD* motifs interacting with the Gt(alpha) C-terminal peptide, in compliance with the structure of the latter. A concomitant role of Gt(alpha) and Gt(gamma) C-termini in stabilizing RD* could possibly be resolved assuming a receptor dimer as requisite for G protein activation.

Published

2004-03-31

Issue

Vol. 51 No. 1 (2004)

Section

Articles

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