Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell.

Anna-Maria Ochocka; Tadeusz Pawelczyk

doi:10.18388/abp.2003_3634

Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell.

Anna-Maria Ochocka Department of Molecular Medicine, Medical University of Gdańsk, Gdańsk, Poland. ochocka@amg.gda.pl;
Tadeusz Pawelczyk

DOI: https://doi.org/10.18388/abp.2003_3634

Abstract

Phospholipase C (PLC, EC 3.1.4.11) is an enzyme crucial for the phosphoinositol pathway and whose activity is involved in eukaryotic signal transduction as it generates two second messengers: diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). There are four major types of phospholipase C named: beta, gamma, delta and the recently discovered epsilon, but this review will focus only on the recent advances for the delta isozymes of PLC. So far, four delta isozymes (named delta1-4) have been discovered and examined. They differ with regard to cellular distribution, activities, biochemical features and involvement in human ailments.

Published

2003-12-31

Issue

Vol. 50 No. 4 (2003)

Section

Articles

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