The network of calcium regulation in muscle.

Anthony N Martonosi; Slawomir Pikula

doi:10.18388/abp.2003_3711

The network of calcium regulation in muscle.

Anthony N Martonosi State University of New York, Upstate Medical University, College of Graduate Studies, Syracuse, New York, USA.;
Slawomir Pikula

DOI: https://doi.org/10.18388/abp.2003_3711

Abstract

In this review the molecular characteristics and reaction mechanisms of different Ca(2+) transport systems associated with various membranes in muscle cells will be summarized. The following topics will be discussed in detail: a brief history of early observations concerning maintenance and regulation of cellular Ca(2+) homeostasis, characterization of the Ca(2+) pumps residing in plasma membranes and sarco(endo)plasmic reticulum, mitochondrial Ca(2+) transport, Ca(2+)-binding proteins, coordinated expression of Ca(2+) transport systems, a general background of muscle excitation-contraction coupling with emphasis to the calcium release channels of plasma membrane and sarcoplasmic reticulum, the structure and function of dihydropyridine and ryanodine receptors of skeletal and cardiac muscles, and finally their disposition in various types of muscles.

Published

2003-03-31

Issue

Vol. 50 No. 1 (2003)

Section

Articles

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