Directionality of kinesin motors.

Andrzej A Kasprzak; Łukasz Hajdo

doi:10.18388/abp.2002_3741

Directionality of kinesin motors.

Andrzej A Kasprzak Department of Muscle Biochemistry, Nencki Institute of Experimental Biology, L Pasteura 3, 020-093 Warszawa, Poland. aak@nencki.gov.pl;
Łukasz Hajdo

DOI: https://doi.org/10.18388/abp.2002_3741

Abstract

Kinesins are molecular motors that transport various cargoes along microtubule tracks using energy derived from ATP hydrolysis. Although the motor domains of kinesins are structurally similar, the family contains members that move on microtubules in opposite directions. Recent biochemical and biophysical studies of several kinesins make it possible to identify structural elements responsible for the different directionality, suggesting that reversal of the motor movement can be achieved through small, local changes in the protein structure.

Published

2002-12-31

Issue

Vol. 49 No. 4 (2002)

Section

Articles

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