Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells.

Lidiya Nosach; Nataliya Dyachenko; Valentina Zhovnovataya; Miron Lozinskiy; Victor Lozitsky

doi:10.18388/abp.2002_3760

Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells.

Lidiya Nosach Institute of Microbiology and Virology NAS of Ukraine, Kyiv, Ukraine. Dyachenko@serv.imv.kiev.ua;
Nataliya Dyachenko
Valentina Zhovnovataya
Miron Lozinskiy
Victor Lozitsky

DOI: https://doi.org/10.18388/abp.2002_3760

Abstract

Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs epsilon-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. Proteolytic processing may be regarded as one of the targets for inhibiting adenovirus reproduction.

Published

2002-12-31

Issue

Vol. 49 No. 4 (2002)

Section

Articles

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