Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas.

Krystyna Urbanska; Bozena Romanowska-Dixon; Zenon Matuszak; Janusz Oszajca; Patrycja Nowak-Sliwinska; Grazyna Stochel

doi:10.18388/abp.2002_3797

Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas.

Krystyna Urbanska Institute of Molecular Biology and Biotechnology, Ophthalmology Department, Collegium Medicum, Jagiellonian University, Kraków, Poland. Urbanska@mol.uj.edu.pl;
Bozena Romanowska-Dixon
Zenon Matuszak
Janusz Oszajca
Patrycja Nowak-Sliwinska
Grazyna Stochel

DOI: https://doi.org/10.18388/abp.2002_3797

Abstract

Spectroscopic, photochemical and biological properties of indocyanine green (ICG) are presented. Light over 800 nm is effectively absorbed by ICG. This property as well as photochemical behaviour of ICG make it a very suitable dye for photodynamic treatment of melanoma cells. Cytotoxicity of ICG itself and the effect of photodynamic therapy (PDT) were evaluated by following the growth of human (SKMEL 188) and mouse (S91) melanoma cells. The surviving fraction of the cells irradiated (lambda(ex) = 830 nm) vs non-irradiated, treated with the same dose of ICG, is significantly decreased (5- to 10-fold). These results show that ICG is a very promising dye for photodynamic therapy of melanomas.

Published

2002-06-30

Issue

Vol. 49 No. 2 (2002)

Section

Articles

Acta Biochimica Polonica is an OpenAccess quarterly and publishes four issues a year. All contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.