Enhanced microdialysis of neuropeptides.

A Pettersson; K Markides; J Bergquist

doi:10.18388/abp.2001_3875

Enhanced microdialysis of neuropeptides.

A Pettersson Department of Analytical Chemistry, Uppsala University, Sweden.;
K Markides
J Bergquist

DOI: https://doi.org/10.18388/abp.2001_3875

Abstract

An enhanced microdialysis method for neuropeptides is described and some preliminary results of this novel approach are presented. The enhancement is achieved by adding a vehicle (solid support) to the perfusion fluid in order to increase the diffusion coefficient across the membrane and efficiently transport the analytes towards the detector. The microdialysis samples are desalted and then analyzed on an electrospray ionization orthogonal time-of-flight mass spectrometer. The preliminary results show major increase in signal when comparing this new approach of microdialysis with ordinary microdialysis.

Published

2001-12-31

Issue

Vol. 48 No. 4 (2001)

Section

Articles

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