Design, synthesis and biological evaluation of a new bridged immunosuppressor.

Z Szewczuk; A Wilczyński; I Petry; I Z Siemion; Z Wieczorek

doi:10.18388/abp.2001_3881

Design, synthesis and biological evaluation of a new bridged immunosuppressor.

Z Szewczuk Faculty of Chemistry, University of Wrocław, Poland. szewczuk@wchuwr.chem.uni.wroc.pl;
A Wilczyński
I Petry
I Z Siemion
Z Wieczorek

DOI: https://doi.org/10.18388/abp.2001_3881

Abstract

A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-gamma-Abu-Asn-Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was designed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral immune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.

Published

2001-12-31

Issue

Vol. 48 No. 4 (2001)

Section

Articles

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