Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I.

P Zubrzak; K Kociołek; M Smoluch; J Silberring; M L Kowalski; B Szkudlińska; J Zabrocki

doi:10.18388/abp.2001_3882

Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I.

P Zubrzak Institute of Organic Chemistry, Technical University of Lódź, Poland.;
K Kociołek
M Smoluch
J Silberring
M L Kowalski
B Szkudlińska
J Zabrocki

DOI: https://doi.org/10.18388/abp.2001_3882

Abstract

Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2-Pro3 Pro3-Pro4 and Val6-Pro7 replaced by their tetrazole analogues Ile2-psi[CN4]-Ala3', Pro3-psi[CN4]-Ala4 and Val6-psi[CN4]-Ala7 were synthesized by the solid phase peptide synthesis method and cyclized with the TBTU and/or HATU reagent. The peptides were examined for their immunosuppressive activity in the lymphocyte proliferation test (LPT).

Published

2001-12-31

Issue

Vol. 48 No. 4 (2001)

Section

Articles

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