Cellular aspects of folate and antifolate membrane transport.

A Brzezińska; P Wińska; M Balińska

doi:10.18388/abp.2000_3992

Cellular aspects of folate and antifolate membrane transport.

A Brzezińska Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warszawa.;
P Wińska
M Balińska

DOI: https://doi.org/10.18388/abp.2000_3992

Abstract

Folates--one carbon carriers--take part in the metabolism of purine, thymidylate and some amino acids. Internalization of these compounds employs several mechanisms of transport systems. Reduced folate carriers and folate receptors play the most important role in this process. The physiological role of these molecules in normal and neoplastic cells is described regarding changes in transport activity and connection of transport systems with resistance to antifolates and cancer development.

Published

2000-09-30

Issue

Vol. 47 No. 3 (2000)

Section

Articles

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